Porphobilinogen synthase (PBGS) is the prototype morpheein.Įnsemble models of allosteric regulation enumerate an allosteric system's statistical ensemble as a function of its potential energy function, and then relate specific statistical measurements of allostery to specific energy terms in the energy function (such as an intermolecular salt bridge between two domains). The required oligomer disassembly step differentiates the morpheein model for allosteric regulation from the classic MWC and KNF models. Transitions between alternate morpheein assemblies involve oligomer dissociation, conformational change in the dissociated state, and reassembly to a different oligomer. Ī morpheein is a homo-oligomeric structure that can exist as an ensemble of physiologically significant and functionally different alternate quaternary assemblies. The morpheein model of allosteric regulation is a dissociative concerted model. ![]()
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